Charles Fabrikant served as CEO-Chairman of Seacor Holdings, Inc. from 1991 to 2022. In 1992, he founded and developed the Emergency Response Group, National Response Corporation (NRC), which played a pivotal role in hurricane and oil spill responses. He orchestrated the acquisition of Tex-Air in 2001, a 50-asset single-engine rotary service, followed by ERA Aviation in 2005—an operator offering fixed-wing service in Alaska (Dash-8s and Twin Otters), seasonal and local rotary operations, offshore support in the Gulf of Mexico, and Anchorage FBO operations. In 2006–2007, Fabrikant entered a joint venture with Avion Pacific, Sikorsky’s distributor in China, to finance aircraft sales and represent Hawker aircraft across Asia.

From 2007 to 2022, Fabrikant served as Chairman of the ERA Board and Interim CEO, overseeing major fleet renovations, including becoming the launch customer for the AW139 (now Leonardo) and AW189 helicopters, and expanding into Brazil. ERA became the only oil industry rotary service provider to avoid bankruptcy under his leadership. The fleet included a wide range of aircraft—212s, 412s, 225s, 139s, 119s, A-stars, 135s, 145s—and firefighting aircraft supported by joint ventures in Spain and Chile. He led ERA's 2020 merger with Bristow and served as Director of Bristow from 2021 to 2022, supporting global search and rescue contracts in the UK, Norway, Netherlands, Ireland, and the Falklands.

Beyond aviation, Fabrikant supervised NRC’s coordinated response to the 2010 Macondo well blowout, working alongside FEMA, the US Coast Guard, and state governments. Between 2010–2012, he funded a Hong Kong-based warehouse and parts operation with Avion Pacific to stabilize Asia’s aircraft supply chain. From 2012 to 2019, he facilitated a 33% investment in Hawker Pacific—expanding operations across Australia, New Zealand, Malaysia, and Singapore—and later sold the company to General Dynamics. He also funded Twin Otter and Hawker leases in Argentina and Asia. From 2020 to 2022, he served as a consultant to Asian Sky Group, where he supported aircraft sales, charter brokerage, and rotary aviation publishing, and helped launch a virtual air show using MYTAVERSE VR during the COVID-19 shutdown.